Dr.Martinez said:The dose-response is real but shallow at the top.
That holds for the injectable. The oral formulation has different absorption behaviour and the dose numbers are not interchangeable, which is worth saying out loud because people quote them as if they were.
Dr.NateNeph said:All true, with one condition: that curve is for people who reached the dose on schedule.
Saving this. It is the first explanation that did not require me to already understand it.
Dr.Martinez said:The dose-response is real but shallow at the top.
This is where I part company with the consensus forming above. The trial means are being read too generously in this thread. STEP populations were selected, supported, and titrated by protocol, and the real-world curves are consistently a few points worse. That difference is not noise, it is what happens when you remove the study infrastructure.
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Shop Reference StandardsRunnerRach said:Training four times a week throughout and the scale has barely acknowledged it, which is demoralising in a way I did not expect.
Exercise transformation with training: went from barely able to walk a block to completing a half marathon last Saturday.
My fitness journey alongside GLP-1 therapy:
- Month 1-2: Walking 15 min/day
- Month 3-4: Walking 30-45 min, started bodyweight exercises
- Month 5-6: Joined a gym, started resistance training
- Month 7+: Running, lifting heavy, cycling for fun
The weight loss made movement possible. The movement made more weight loss possible. Virtuous cycle in action.
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