julia.endo said:Muscle fiber type changes during GLP-1-mediated weight loss, relevant to lean mass: preliminary biopsy data suggests that weight loss shifts the…
Sharing my comprehensive lab data relevant to lean mass:
| Biomarker | Baseline | Month 3 | Month 6 | Month 9 |
|---|---|---|---|---|
| Weight (lbs) | 286 | 261 | 236 | 201 |
| A1C (%) | 7.6 | 6.6 | 5.9 | 5.3 |
| hsCRP (mg/L) | 6.0 | 5.0 | 1.5 | 1.2 |
| Triglycerides | 246 | 146 | 146 | 116 |
Protocol: Semaglutide 2.4mg/wk, resistance training 3x/week, protein 1.4g/kg/day.
The improvements in lean mass are clearly reflected in these numbers. The inflammatory marker reduction (hsCRP) is particularly striking.
PurityPaulOR said:Agreed on the ranges, with the condition that a single DEXA is not a measurement, it is one draw from a distribution.
Saving this. It is the first explanation that did not require me to already understand it.
julia.endo said:Muscle fiber type changes during GLP-1-mediated weight loss, relevant to lean mass: preliminary biopsy data suggests that weight loss shifts the…
OMG yes. lean mass + resistance training is the combo. Can confirm.
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Browse GL Biochememily_PDX said:I lifted three times a week throughout and still lost lean mass.
My endo's protocol for lean mass plateau: if weight loss stalls for 6+ weeks at current dose, we go through this checklist before titrating up:
- Food diary review — is intake creeping up?
- Protein check — minimum 100g/day
- Activity audit — steps + resistance training
- Sleep quality — poor sleep kills GLP-1 efficacy
- Stress/cortisol management
Only after addressing all of these do we increase the dose. Often fixing one lifestyle factor restarts progress without needing more medication.
Moderator note: leaving this open. It is being argued well and the disagreement is the useful part. Tagging this one for the weekly digest.