JenPlateau said:There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.
Agreed, though "tolerable" needs defining. A dose you tolerate by eating almost nothing is not tolerated, it is being paid for somewhere else — usually in lean mass, sometimes in adherence three months later.
Dr.PathRoch said:Steady state is the thing most people miss.
Bookmarking. The distinction being drawn above is the one nobody else makes.
JenPlateau said:There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.
Filing a mild objection. Mild because I might be wrong; an objection because nobody has addressed the case that does not fit. The trial means are being read too generously in this thread. STEP populations were selected, supported, and titrated by protocol, and the real-world curves are consistently a few points worse. That difference is not noise, it is what happens when you remove the study infrastructure.
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View ResultsThe figures, for anyone assembling their own picture. Give anything pharmacological four weeks before you judge it, and give anything measured weekly a four-point rolling average before you call it a trend.