julia.endo said:Back pain as a lean mass side effect: not from the medication itself, but from rapid body composition changes.
Same pattern here, and in the same order. Posting only so the count is not one.
wendy_avl said:hannah_MT said: ...the muscle loss concern with lean mass...
OMG yes. lean mass + resistance training is the combo. Can confirm.
wendy_avl said:hannah_MT said: ...the muscle loss concern with lean mass...
Physical therapist weighing in on lean mass. I work with bariatric and metabolic patients daily.
The resistance training evidence is critical here:
The Lundgren 2024 JAMA paper[1] showed that structured resistance training preserved 73% more lean mass in GLP-1 patients vs medication alone. When discussing lean mass, we MUST include the exercise component.
My minimum prescription: 3x/week compound movements (squat, deadlift, press, row), progressive overload, 7-10K steps/day, and 1.2-1.6g protein/kg/day.
[1] Lundgren JR, et al. JAMA. 2024;331(1):38-48.
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Browse GL BiochemA narrower follow-up, since the general answer is now clear:
Did your prescriber agree with that reading, and if not what was their objection?
Moderator note: the sourcing question belongs in the vendor section and has been split out. Tagging this one for the weekly digest.