TrialNerd_Beth said:Training does two things here and only one of them is on the scale.
I read this differently from TrialNerd_Beth, on substance rather than tone. I would be careful about how confidently the flatness reports get attributed. Rapid weight loss, a large deficit and disrupted sleep produce low mood on their own, and separating that from a drug effect is genuinely hard.
JenMemphis said:The weight came off and the harder part started, which is not what any of the material I read had prepared me for.
Mood changes on mental health: I want to be transparent — I went through a rough patch emotionally around month 3. Not depression exactly, but a weird flatness. Food was my main coping mechanism and without that, I had to develop new ones.
Therapy has been essential. I'd strongly recommend anyone starting GLP-1 therapy also invest in mental health support. The physical transformation is only half the journey.
PeptideChemSF said:I would be careful about how confidently the flatness reports get attributed.
When to call your doctor about mental health side effects — a reference I wish I'd had:
Call immediately:
- Severe abdominal pain (could be pancreatitis)
- Vision changes (thyroid concern)
- Lump in neck (thyroid nodule)
- Severe vomiting/can't keep fluids down for 24h+
Schedule an appointment:
- Persistent nausea beyond 4 weeks
- Significant hair loss
- Mood changes or depression
- Gallbladder symptoms (RUQ pain after eating)
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Browse GL BiochemA narrower follow-up, since the general answer is now clear:
What training is actually for during a large deficit, because framing it as calorie burn sets people up to quit when the arithmetic disappoints them?
OP back with an update, since a thread like this is useless without one.
Follow-up — I put something in the gap where food used to be rather than waiting for the gap to close on its own. That was the part nobody told me.