Dr.BariatricHTX said:Vitamin deficiency cascade with cardiovascular risk: after 6+ months of reduced food intake, I developed a subtle but important pattern: low B12 →…
Metabolic syndrome resolution on cardiovascular risk: I went from meeting 3 of 5 diagnostic criteria to meeting ZERO after 11 months of treatment.
The 5 criteria (and my journey):
- Waist circumference: 50" → 34" ✅ Resolved
- Triglycerides: 264 → 99 ✅ Resolved
- HDL: 34 → 56 ✅ Resolved
- Blood pressure: 144/90 → 122/76 ✅ Resolved
- Fasting glucose: 129 → 86 ✅ Resolved
Metabolic syndrome reversal is, in my view, the most medically significant outcome of GLP-1 therapy.
matt_MKE said:Fair, but phase 2 tolerability figures rarely survive contact with phase 3 scale.
Bookmarking. The distinction being drawn above is the one nobody else makes. Taking it to my next appointment.
Dr.BariatricHTX said:Vitamin deficiency cascade with cardiovascular risk: after 6+ months of reduced food intake, I developed a subtle but important pattern: low B12 →…
I would rather people stopped quoting the 24% as if it were a licensed outcome. It is a phase 2 result in a few hundred participants with no cardiovascular endpoint and no long-term safety data, and this board has a habit of treating pipeline numbers as settled.
Worth separating that from retatrutide, which this thread keeps folding into the same question. They behave differently and the advice does not transfer.
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Browse GL BiochemSleepDoc_PDX said:Prescribed on cardiovascular grounds rather than for weight, and almost everything written for patients assumes the opposite.
NNT calculation for cardiovascular risk clinical endpoints: NNT = 1/ARR (absolute risk reduction).
From SELECT trial: MACE at 39 months — 6.5% semaglutide vs 8.0% placebo. ARR = 1.5%. NNT = 67 over 3.3 years.
Compare to established therapies:
| Intervention | NNT | Timeframe |
|---|---|---|
| Semaglutide (MACE) | 67 | 3.3 years |
| Statins primary prevention (MI) | ~100 | 5 years |
| Aspirin secondary prevention | ~77 | 2 years |
These NNTs are clinically meaningful and comparable to accepted cardiovascular interventions.