Dr.ObesityMed said:CRP reduction on cardiovascular risk — this is the lab result that excites me most: Baseline hsCRP: 10.0 mg/L (high cardiovascular risk) Month 6…
6 month update on cardiovascular risk: down 58 lbs, off blood pressure meds, A1C normalized. Genuinely life-changing.
FDA_TrackerJim said:Dizziness and cardiovascular risk: I was lightheaded for the first 2 weeks.
This is exactly what I could not find anywhere else. Printing the relevant bit and taking it with me.
Dr.ObesityMed said:CRP reduction on cardiovascular risk — this is the lab result that excites me most: Baseline hsCRP: 10.0 mg/L (high cardiovascular risk) Month 6…
SUSTAIN-6 was the first CVOT to show cardiovascular benefit with semaglutide, relevant to cardiovascular risk. In 3,297 T2DM patients with high CV risk: MACE HR 0.74 (95% CI 0.58-0.95, p=0.02)[1].
Notable: the retinopathy signal in SUSTAIN-6 (HR 1.76) was subsequently attributed to rapid A1C reduction in patients with pre-existing retinopathy — not a direct drug effect. This has been confirmed in longer-term follow-up studies.
[1] Marso SP, et al. N Engl J Med. 2016;375(19):1834-1844.
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Browse GL BiochemInsuranceTom said:My reason for being on this is cardiovascular rather than cosmetic, which puts me in a small minority in most of these threads.
I'm 62 years old and want to share my perspective on cardiovascular risk as an older member of this community.
My doctor was initially hesitant because of my age, but the SELECT trial included patients up to 72 and showed consistent benefit across age groups. We started at the lowest dose with closer monitoring.
9 months later: down 56 lbs, off lisinopril, A1C from 7.2% to 5.3%. My cardiologist is thrilled. cardiovascular risk is absolutely relevant for older adults — don't let anyone tell you otherwise.
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