Dr.PathRoch said:PharmacoVig_BOS said: ...cardiovascular risk is just another fad...
6 month update on cardiovascular risk: down 50 lbs, off blood pressure meds, A1C normalized. Genuinely life-changing.
Dr.PathRoch said:PharmacoVig_BOS said: ...cardiovascular risk is just another fad...
Dr.PathRoch said:...we're creating a generation dependent on cardiovascular risk...
I understand the concern, but consider this analogy: are we "creating a generation dependent on" blood pressure medication? Cholesterol medication? Thyroid medication?
Obesity is a chronic disease with biological drivers. Treating it with medication is no different from treating any other chronic condition. The "dependency" framing implies weakness or moral failure — neither of which is accurate.
If ongoing medication is what keeps someone healthy, that's successful treatment, not dependency.
Dr.PathRoch said:PharmacoVig_BOS said: ...cardiovascular risk is just another fad...
Thank you for spelling out the reasoning rather than just the conclusion.
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NNT calculation for cardiovascular risk clinical endpoints: NNT = 1/ARR (absolute risk reduction).
From SELECT trial: MACE at 39 months — 6.5% semaglutide vs 8.0% placebo. ARR = 1.5%. NNT = 67 over 3.3 years.
Compare to established therapies:
| Intervention | NNT | Timeframe |
|---|---|---|
| Semaglutide (MACE) | 67 | 3.3 years |
| Statins primary prevention (MI) | ~100 | 5 years |
| Aspirin secondary prevention | ~77 | 2 years |
These NNTs are clinically meaningful and comparable to accepted cardiovascular interventions.
hyun_seoul said:NNT calculation for cardiovascular risk clinical endpoints: NNT = 1/ARR (absolute risk reduction).
Second this.