Same technique for eight months and the site reactions started in month nine, which rules out most of what I assumed the cause was.
So the question, as narrowly as I can put it: whether site reactions are a material issue or a technique issue, and what people changed that actually helped.
Not looking for reassurance. Looking for the part I have got wrong.
Short answer first, then the reasoning. Relative and absolute effects need reading together. A 20% relative reduction on a high baseline risk is a large absolute benefit; the same relative figure on a low baseline risk is a small one, and press summaries almost always quote the relative number because it is bigger.
Dr.KarenChen said:Relative and absolute effects need reading together.
Agreed, and subgroup analyses deserve particular suspicion. With enough subgroups something is significant by chance, and pre-registered subgroups are a different animal from ones found afterwards.
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View Resultstyler_CSCS said:Same technique for eight months and the site reactions started in month nine, which rules out most of what I assumed the cause was.
This is my experience too, for whatever a second data point is worth.
Adding the clinical framing, because it changes how the question reads.
Helpful tip for injection-site reactions needle anxiety: ice the injection site for 30 seconds before injecting. You'll barely feel the 30g needle go in. I went from dreading injection day to not even flinching.
Also, don't watch the needle enter your skin. Look away, take a deep breath, and it's over in seconds.