newstart_MO said:Order of operations matters more than any single choice here: establish a baseline, change one thing, wait long enough for it to express itself, then…
Agreed, though "tolerable" needs defining. A dose you tolerate by eating almost nothing is not tolerated, it is being paid for somewhere else — usually in lean mass, sometimes in adherence three months later.
AttorneyGrant said:The mechanism that matters here is not stomach emptying, it is central.
Thank you — that is the clearest version of this I have read, and I have read a lot of them.
newstart_MO said:Order of operations matters more than any single choice here: establish a baseline, change one thing, wait long enough for it to express itself, then…
I will push back on the "any working dose is fine" framing. The maintenance evidence sits overwhelmingly at the top studied dose, and the extension data shows regain tracking dose reduction rather than tracking stopping. Holding low is reasonable; pretending it is evidentially equivalent is not.
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I would rather be corrected than agreed with, if it comes to it.