LindaRN_retired said:The version of this that has an answer is narrower than the version being asked.
Agreed, though "tolerable" needs defining. A dose you tolerate by eating almost nothing is not tolerated, it is being paid for somewhere else — usually in lean mass, sometimes in adherence three months later.
RickReta_CO said:The mechanism that matters here is not stomach emptying, it is central.
Thank you — that is the clearest version of this I have read, and I have read a lot of them. I will report back once I have actually tried it.
LindaRN_retired said:The version of this that has an answer is narrower than the version being asked.
Pushing back on LindaRN_retired here. The trial means are being read too generously in this thread. STEP populations were selected, supported, and titrated by protocol, and the real-world curves are consistently a few points worse. That difference is not noise, it is what happens when you remove the study infrastructure.
If somebody has the primary source to hand I would rather cite it than paraphrase it.
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View ResultsOne concrete data point for the thread. Give anything pharmacological four weeks before you judge it, and give anything measured weekly a four-point rolling average before you call it a trend.
Happy to go further on any of that.