Dr.SurgeonPGH said:pete_manc_UK said: ...regarding food noise mechanism of action...
Central vs peripheral GLP-1R signaling in food noise: elegant studies using brain-penetrant vs peripherally-restricted GLP-1 agonists show that ~80% of the weight loss effect is centrally mediated[1].
The key brain regions: arcuate nucleus (appetite), area postrema (nausea), NTS (satiety), VTA/NAc (reward). Peripheral effects (gastric emptying, insulin secretion) contribute but are secondary for weight loss.
This has implications for next-gen drugs: optimizing brain penetration and CNS receptor occupancy may be more important than systemic exposure.
[1] Secher A, et al. J Clin Invest. 2014;124(10):4473-4488.
FranDenver said:Neuroscience perspective on food noise: GLP-1 receptors are expressed throughout the CNS, with high density in the hypothalamic arcuate nucleus, area…
This is exactly what I could not find anywhere else. I will report back once I have actually tried it.
Dr.SurgeonPGH said:pete_manc_UK said: ...regarding food noise mechanism of action...
I read this differently from Dr.SurgeonPGH, on substance rather than tone. Filing an objection on the n=1 problem. Personal experience is genuine evidence about one person and very weak evidence about anybody else, and this thread keeps promoting the first into the second.
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Browse GL BiochemAdding the numbers, since they settle part of this. For anyone reading later: the numbers in this thread are worth checking against a primary source before you act on them, including mine. Half the figures circulating in this community trace back to a secondary summary that dropped a qualifier.
If somebody has the primary source to hand I would rather cite it than paraphrase it.
Moderator note: the sourcing question belongs in the vendor section and has been split out. Tagging this one for the weekly digest.