From the other side of the consultation, briefly. The useful move here is to separate what is established from what is widely repeated. Those two sets overlap less than the confident tone of most write-ups suggests, and the second set is where nearly all the disagreement on this board comes from.
Correct me if the detail matters more than I have assumed.
ingrid_STO said:The useful move here is to separate what is established from what is widely repeated.
Mine went the same way, slower. Posting only so the count is not one.
ingrid_STO said:The useful move here is to separate what is established from what is widely repeated.
Adding the part of the answer the thread has not reached. The pharmacokinetics explain nearly every practical question asked here. Albumin binding above 99% slows clearance enough to make weekly dosing possible; a terminal half-life near a week means four to five weeks to steady state and therefore a four-week titration interval; subcutaneous bioavailability around 89% means injection site barely matters. Those three facts answer most timing questions before they are asked.
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Browse GL BiochemAdding the numbers, since they settle part of this. Keep the original post as written when you update it, and add the correction underneath. An edited-away mistake is invisible to the next person who makes it.
Moderator note: two posts asking for a source have been merged into one. Please search the thread before asking again. Carry on.