NurseAsh_DET said:The mechanism is more central than most summaries suggest.
Agreed, and the adaptation point cuts both ways: tachyphylaxis to gastric emptying is why tolerability improves, and it is also why people who were relying on physical fullness feel the effect fade while the appetite effect is still working.
JessicaH_TX said:Agreed on the mechanism, with the caveat that the head-to-head used semaglutide 1mg, not 2.4mg.
Thank you — that is the clearest version of this I have read, and I have read a lot of them. Taking it to my next appointment.
NurseAsh_DET said:The mechanism is more central than most summaries suggest.
I read this differently from NurseAsh_DET, on substance rather than tone. Not convinced. The evidence being cited is consistent with the conclusion and also consistent with two other conclusions nobody has ruled out.
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Browse GL BiochemThe figures, for anyone assembling their own picture. If you are going to change something, change one thing and give it long enough to express itself. Four weeks is the usual minimum for anything pharmacological on this board, and two weeks of data has told you almost nothing.
Correct me if the detail matters more than I have assumed.