Dr.RenalNash said:Alcohol relationship change with food noise: I used to drink 3-4 beers most nights.
The GLP-1 and alcohol use disorder connection, relevant to food noise: observational data from Scandinavian registries shows reduced alcohol-related hospitalizations in GLP-1 agonist users[1].
The mechanism is plausible: GLP-1R is expressed in the mesolimbic reward pathway (VTA, nucleus accumbens). Agonism at these receptors may reduce the reinforcing properties of alcohol, similar to the reduction in "food noise."
RCTs for GLP-1 agonists in AUD are now underway. If positive, this would be a paradigm-shifting repurposing of existing medications.
[1] Wang W, et al. Nat Med. 2024;30:574-584.
maya_sedona said:"Food aversion" side effect of food noise that I wasn't prepared for: I used to LOVE cooking and trying new restaurants.
That reframing is the part I needed. Sending this to two other people who asked me the same thing last week.
Dr.RenalNash said:Alcohol relationship change with food noise: I used to drink 3-4 beers most nights.
Worth saying that the confident version of this is more useful to the person writing it than to the person reading it.
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