SarahChen_PharmD said:PK/PD modeling for the pharmacology: understanding the pharmacokinetics helps optimize dosing.
That holds where the measurement is reliable. Where it is noisy — and a lot of what gets tracked here is noisy — the same reasoning produces confident nonsense.
HPLC_Greg said:The pharmacokinetics explain nearly every practical question asked here.
That reframing is the part I needed. Adding it to my notes with a link back to this thread.
SarahChen_PharmD said:PK/PD modeling for the pharmacology: understanding the pharmacokinetics helps optimize dosing.
Pushing back on SarahChen_PharmD here. Not convinced. The evidence being cited is consistent with the conclusion and also consistent with two other conclusions nobody has ruled out.
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Browse GL BiochemThe figures, for anyone assembling their own picture. If you are comparing against somebody else’s result, check that you are comparing the same measurement taken the same way. Most of the apparent contradictions in these threads dissolve at that step.
I would rather be corrected than agreed with, if it comes to it.
Moderator note: leaving this open. It is being argued well and the disagreement is the useful part. Thread quality here is what the rules are for. Keep it up.