andrew_nyc said:Receptor pharmacology relevant to the pharmacology: semaglutide is a GLP-1R agonist with a C-18 fatty acid chain that enables albumin binding (>99%),…
Thank you — that is the clearest version of this I have read, and I have read a lot of them. I will report back once I have actually tried it.
From the other side of the consultation, briefly. Start from the measurement rather than the conclusion. Almost every disagreement here turns out to be two people measuring different things and comparing the numbers anyway.
sarah_TO said:PK/PD modeling for the pharmacology: understanding the pharmacokinetics helps optimize dosing.
I read this differently. The confidence in this thread is running ahead of the evidence, and I would rather the uncertainty were stated than smoothed over because it is unsatisfying.
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Moderator note: good thread. Keeping it here rather than moving it, because the question is general enough to be useful.