Jul 13, 2025 at 10:25 AM#11
ingrid_STO said:The mechanism and the magnitude are separate questions.
Fair, and it stops being fair at the extremes. The middle of the range is well understood; the ends are where the honest answer is that nobody knows.
Last edited: Jul 13, 2025 at 1:25 PM
48 21steve_okc, dave_SLC, FDA_TrackerJim and 45 others
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Jul 13, 2025 at 4:59 PM#12
stefan_berlin said:Agreed, with a caveat about community reputation: it is a lagging indicator.
This is exactly what I could not find anywhere else.
Last edited: Jul 13, 2025 at 10:59 PM
49 22BiostatsBrad, PeptideSynthNJ, Dr.KarenChen and 46 others
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Jul 13, 2025 at 11:33 PM#13
ingrid_STO said:The mechanism and the magnitude are separate questions.
Pushing back on ingrid_STO here. This treats a plausible mechanism as a demonstrated one. Plausible is where you start looking, not where you stop.
Happy to go further on any of that.
Last edited: Jul 14, 2025 at 4:33 AM
50 23rachel_ABQ, traveltech_sara, AttorneyGrant and 47 others
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View ResultsJul 14, 2025 at 6:07 AM#14
Adding the numbers, since they settle part of this. Give anything pharmacological four weeks before you judge it, and give anything measured weekly a four-point rolling average before you call it a trend.
1 24Dr.LeslieOBGYN
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