SarahChen_PharmD said:Bone density monitoring on lean mass: DEXA bone density at baseline and month 12.
Sharing my comprehensive lab data relevant to lean mass:
| Biomarker | Baseline | Month 3 | Month 6 | Month 9 |
|---|---|---|---|---|
| Weight (lbs) | 251 | 241 | 221 | 196 |
| A1C (%) | 7.6 | 6.1 | 5.6 | 5.3 |
| hsCRP (mg/L) | 6.0 | 5.0 | 2.5 | 0.7 |
| Triglycerides | 191 | 141 | 111 | 101 |
Protocol: Tirzepatide 15mg/wk, resistance training 4x/week, protein 1.6g/kg/day.
The improvements in lean mass are clearly reflected in these numbers. The inflammatory marker reduction (hsCRP) is particularly striking.
SarahChen_PharmD said:Bone density monitoring on lean mass: DEXA bone density at baseline and month 12.
Physical therapist weighing in on lean mass. I work with bariatric and metabolic patients daily.
The resistance training evidence is critical here:
The Lundgren 2024 JAMA paper[1] showed that structured resistance training preserved 73% more lean mass in GLP-1 patients vs medication alone. When discussing lean mass, we MUST include the exercise component.
My minimum prescription: 3x/week compound movements (squat, deadlift, press, row), progressive overload, 7-10K steps/day, and 1.2-1.6g protein/kg/day.
[1] Lundgren JR, et al. JAMA. 2024;331(1):38-48.
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View Resultskate.chem said:Physical therapist weighing in on lean mass.
Careful with the causal language. Two things moving together in a period when five things changed is not a mechanism, and stating it as one makes the thread less useful to somebody reading it later.
kate.chem said:Physical therapist weighing in on lean mass.
True, with the qualification that this is a self-selected group. The people for whom it did not work post less, and that shapes everything we think we know.